Publications
Invention
Kornilov P, Peretz A, Lee Y, Son K, Lee JH, Refaeli B, Roz N, Rehavi M, Choi S, Attali B. (2014) Promiscuous gating modifiers target the voltage sensor of Kv7.2, TRPV1, and Hv1 cation channels. FASEB J. 28:2591-602.
Peretz A, Pell L, Gofman Y, Haitin Y, Shamgar L, Patrich E, Kornilov P, Gourgy-Hacohen O, Ben-Tal N, Attali B. (2010) Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. PNAS. 107(35):15637-42.
Innovation
PAIN - The Journal of the International Association for the Study of Pain
"Deciphering Bsense's Mode of Action"
Novel mechanism of action targeting transient receptor potential vanilloid type 1 and Kv7.2/3 inhibits neuronal hyperexcitability. Selectively inhibiting nociceptive neuron excitability provides analgesia without side effects, which may extrapolate to human conditions.
Marc Rogers, an ion channel drug discovery expert
“It is an intriguing mechanism directed at validated analgesia proteins (which may co-localise in DRG sensory neurons), and I am keen to find out more about this scaffold… It is incredible to see BSense sharing the limelight alongside heavyweights like Eli Lilly and Vertex.״
